The Colombian attacked on the steepest part of the final wall to win the stage.
The Belgian recently placed seventh at the final World Cup in Hoogerheide.
Belgian riders Quentin Hermans and Xaydee Van Sinaey will miss out on worlds; two Bora-Hansgrohe riders to miss Mallorca.
Quinten Hermans takes a clear win in the Fayetteville mud.
A first World Cup win for Hermans and his team.